Enkephalin-inactivating enzymes.
نویسندگان
چکیده
منابع مشابه
Enkephalin-degrading enzymes in normal and subfertile human semen.
Opioid peptides have been reported to have important functions in human reproduction. Indeed, very high concentrations of enkephalins and their degrading enzymes have been reported in human semen. In the present paper, we compare the activity of two enkephalin-degrading enzymes, aminopeptidase N and neutral endopeptidase 24.11, in different fractions of semen from normozoospermic, fertile men a...
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UK-18,892, a new semisynthetic aminoglycoside, was active against bacteria possessing aminoglycoside-inactivating enzymes, with the exception of some known to possess AAC(6') or AAD(4') enzymes. This activity has been rationalized by using cell-free extracts of bacteria containing known inactivating enzymes, where it was shown that UK-18,892 was not a substrate for the APH(3'), AAD(2''), AAC(3)...
متن کاملThe Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
Enzymes capable of inactivating tetracycline are paradoxically rare compared with enzymes that inactivate other natural-product antibiotics. We describe a family of flavoenzymes, previously unrecognizable as resistance genes, which are capable of degrading tetracycline antibiotics. From soil functional metagenomic selections, we discovered nine genes that confer high-level tetracycline resistan...
متن کاملEvaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men
Objective The aim of this study was to investigate two enkephalin-degrading enzymes, aminopeptidase N (APN/CD13) and endopeptidase (NEP/CD10), gene and protein expression levels in sperm samples of fertile and heroin-addicted men, and the correlation between their expressions and semen quality. MaterialsAndMethods This case-control study, semen collected from 24 normozoospermic healthy (as a co...
متن کاملAminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics.
Inhibition of aminopeptidase N and neutral endopeptidase-24.11, two zinc metallopeptidases involved in the inactivation of the opioid peptides enkephalins, produces potent physiological analgesic responses, without major side-effects, in all animal models of pain in which morphine is active. Dual inhibitors of both enzymes could fill the gap between opioid analgesics and antalgics. Until now, a...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1993
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.101.4_197